St. Ann's College for Women was established in 1997 with undergraduate programs affiliated to Acharya Nagarjuna University. The college was founded by the late Rev. Mother Mary Ignatius Loyola Mekala, who was the President of the Society of St. Anne. This institution was created to fulfil the vision of its Foundress, Mother Tatipathri Gnanamma, aiming to provide quality education for women.

Academic Programs
In its inaugural academic year of 1997-1998, St. Ann's College offered a limited selection of programs, including:
B.Sc. Programs:
- MPC (Mathematics, Physics, Computer Science)
- MBC (Microbiology, Botany, Chemistry)
B.A. Program:
- MES (Mathematics, Economics, Statistics)
B. Com:
- General

The following academic year, 1998-1999, saw the introduction of additional programs:

B.Sc.Program: MSCs (Mathematics, Statistics, Computer Science)
BCA: Bachelor of Computer Applications
In 1999-2000, the college expanded its offerings to include B. Com (Res-Computer Applications), responding to the evolving needs of society. The college continued to grow, introducing new programs over the years. In the 2003-2004 academic year, it added:
B.Sc. Programs: BBC (Biotechnology, Botany, Chemistry) and MPC (Mathematics, Physics, Chemistry)
Revised Choice Based Credit Curricular Framework in single Major of Government of Andhra Pradesh, in consonance with National Education Policy 2020. The Government of Andhra Pradesh has introduced single major curriculum for all B.Sc/BCA/B.Com/BBA Degree Programmes all across the State of Andhra Pradesh from the academic year 2023-2024.

Postgraduate and Professional Courses :
By 2002-2003, St. Ann's College extended its educational offerings to the postgraduate level with the introduction of the MCA (Master of Computer Applications), which was approved by AICTE New Delhi.
In 2007-2008, the college further enhanced opportunities for its undergraduate students by launching an MBA program, providing a pathway for those seeking higher education.

A Legacy of Excellence: Over the years, St. Ann's College for Women has garnered numerous accolades and recognitions, reflecting our commitment to academic excellence and community service. Here are some highlights of our achievements:

1. September 11, 2008: Awarded the Certificate of Merit for securing Second Prize for Best Performing Professional PG College based on university exam results by Acharya Nagarjuna University during the 32nd Foundation Day celebrations.

2. 2011-2012(09-11-2011): Celebrated the Decennial Celebrations of the MCA Course, marking a decade of quality education.

3. April 3, 2017: Achieved a ranking of 151-200 in the NIRF (National Institutional Ranking Framework), showcasing our academic prowess.

4. September 16, 2017: Honored with the Certificate of Merit for securing First Prize for Best Performing Degree College (outgoing batch of 2016-2017 with over 500 students) by Acharya Nagarjuna University during the 41st Foundation Day celebrations.

5. August 12, 2018: Received an Appreciation Certificate from Guntur Municipal Corporation for our participation in the Guntur 5K RUN Freedom Run.

6. 2019: Awarded a Certificate of Appreciation for outstanding contributions to the Heartfulness Essay Event.

7. September 11, 2019: Recognized with the First Prize for Best Performing Professional PG College (with over 100 students) by Acharya Nagarjuna University during the 43rd Foundation Day celebrations.

8. In response to the growing needs of students, an additional college block was constructed by the management on 26th July 2020. This new facility aims to provide students with enhanced qualitative amenities, ensuring a better educational experience.

9. 12th March 2022: Proudly celebrated our Silver Jubilee, marking 25 years of dedication to empowering women through quality education. This significant milestone reflects our commitment to academic excellence and the transformative impact we have made in the lives of our students.

10. 2022: Received a Certificate of Achievement from Guntur Municipal Corporation for securing Third Prize in the Swachh Competitions at the 75th Aazadi Amrit Mahotsav, highlighting our dedication to cleanliness and environmental awareness in the community.

11. July 12, 2023: Received several certifications from the Nature Science Foundation, including the Best Green Campus Award (valid until August 8, 2025), as well as the Energy Audit Certificate, Environmental Audit Certificate, and Green Campus Audit Certificate.

12. September 26, 2023: Honored with a Certificate of Appreciation by the Red Cross Blood Centre for organizing a voluntary blood donation camp. 13. June 12-13, 2024: Successfully hosted a NAAC Peer Team Visit.

14. June 30, 2024: Awarded Accreditation from the National Assessment and Accreditation Council (NAAC), achieving a CGPA of 3.09 on a four-point scale, receiving an A Grade (valid until June 29, 2029; EC(SC)/205/1st Cycle/APCOGN115791).

15. September 25, 2024: Honored with a Certificate of Appreciation by the Indian Red Cross Society (Guntur District Branch) for Youth Red Cross Volunteer Promotion for the year 2023-2024.

Additionally, our students have excelled in their academic pursuits, receiving gold medals from Acharya Nagarjuna University and Pratibha Puraskarasfrom the Government of Andhra Pradesh for their outstanding performance in university examinations. At St. Ann's, we remain dedicated to fostering an environment of learning, empowerment, and service, shaping the leaders of tomorrow.